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Lepirudin

Alternative Names:Ecarin Chromogenic Assay (ECA)
Laboratory:Haematology
Test Code:LEPI
Specimen Types:Plasma
Container Types:
Sodium Citrate
Adults Volume or Mass:3 mL
Collection & Request Instructions:Only by consult with Lab Haematology Registrar
Deliver to laboratory immediately at room temperature.
Please discuss with the Haematologist (Ext. 63075).  Mark request as "Priority"

Specimens cannot be analysed or re-analysed greater than 2 hours after collection.

.When the collection is by vacuum tube,the coagulation tube should be collected second to avoid artefactual shortening of coagulation assays due to the trauma of venesection.  When syringes are used, have ready two plastic syringes. A butterfly needle may be used. Withdraw 5 mL blood into the first syringe and discard the syringe (or use it for other tests). With the second syringe, withdraw the required amount of blood for the coagulation tests. When blood is collected from an arterial line it is necessary to discard the first 20mL of blood to clear any heparin from the line before collecting the blood for coagulation tests.
Transport Instructions between Sites and/or Laboratories:Send to lab immediately
Assay Frequency:By Arrangement
Additional Notes:

Reference range: 0.2-1.0 ug/mL

The target range for treatment of HIT with or without thrombosis for Lepirudin is 0.6-1.0 ug/mL.
The target range for prophylaxis of patients on lepirudin is 0.2-0.4 ug/mL.
(Reference: Warkentin TE, Greinacher A; Heparin Induced Thrombocytopenia, 4th Edition 2007)