Pathology Handbook

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Mitotane

Laboratory:

Clinical Biochemistry

Test Code:

MITOTANE

Specimen Types:

Plasma

Container Types:

EDTA 10 mL

Adults Volume or Mass:

6 mL

Collection & Request Instructions:

Collect pre-dose

It is recommended that a baseline (pre-treatment) blood sample, a trough level at 1, 2 and 4 weeks after starting treatment, and then regular checks of a trough level every 3 months, be performed.

Transport Instructions between Sites and/or Laboratories:

Send to lab immediately

Assay Frequency:

Fortnightly

External Laboratory:

NSW Health Pathology, Calvary Mater Hospital

Additional Notes:

Ref. Range: 14 -20 mg/L

Serum Mitotane levels above 14 mg/L are associated with optimal therapeutic effect (Haak HR, et al. Br J Cancer 1994.69:947-951). Levels above 20 mg/L are associated with toxicity, mainly gastrointestinal and CNS adverse effects (Van Slooten H et al. Eur J Clin Oncol 1984. 20: 47 - 53, Baudin E et al. Cancer 2001. 92:1385-92).

Note: This test is not Medicare funded. Assay performed by a non NATA accredited research lab- Medical Oncology laboratory at Calvary Mater Newcastle Hospital.

Require Chemical Pathologist/Registrar Approval