Reference Range: < 3.5 mmol/L
LDL is not measured directly but is a calculated value.
As of 20th May 2024, LDL -cholesterol is now calculated using the Sampson-NIH Equation.
Compared to the previously used Friedewald equation, the Sampson-NIH equation is based on the reference method and has accuracy advantages for samples with low LDL-C and/or hypertriglyceridemia up to 9.0 mmol/L.
Where LDL-C calculation by the Friedewald equation is required, this can be performed manually using the equation: LDLC = TC - HDLC - (TG/2.2) (all results in mmol/L).
Reference: Sampson M et al. A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia. JAMA Cardiol 2020;5:540–8. |