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P1NP

Alternative Names:

Procollagen type 1 amino-terminal peptide

Laboratory:

Clinical Biochemistry

Test Code:

P1NP

Specimen Types:

Plasma
Serum

Container Types:

EDTA 6 mL
SST
Lithium Heparin (with Gel)

Collection & Request Instructions:

Marker of bone formation. Useful for monitoring effect of anti-resorptive therapy and patient compliance.

Note: For retrospective test requests;

Serum , K3-EDTA plasma and Li-heparin plasma are stable for 24 hrs at 15 -25 C, 5 days at 2 - 8C, 6 months at -20C. Samples may be frozen and thawed up to 5 times without adverse effects.

K3-EDTA plasma is our preferred specimen.

Transport Instructions between Sites and/or Laboratories:

Room Temperature

Assay Frequency:

Weekdays

Additional Notes:

REFERENCE INTERVALS

P1NP – Serum procollagen type 1 amino-terminal propeptide

Female:

Age	Reference intervals: ug/L
6 – <12 months	840-1800
1 - <2yrs	600-1500
2 - <3yrs	400-1150
3 – <6 yrs	300-900
6 – <11 yrs	410 - 1020
11 - < 12 yrs	110 - 1450
12 –< 15 yrs	110 - 1350
15 - < 16yrs	40 - 510
16 – <20 yrs	50 - 280
20 – <25 yrs	15 - 90
25 – <50 yrs* * This reference interval applies to pre-menopausal women, values can be higher in < 35 y.o.	15 - 70
50 – <70 yrs* * This reference interval applies to post- menopausal women.	15 - 90
≥ 70 yrs	15 - 115

Male:

Age	Reference intervals: ug/L
6 – <12 months	840-1800
1 - <2 yrs	600-1500
2 - <3 yrs	400-1150
3 – <6 yrs	300-900
6 - <12 yrs	410 - 1080
12 – <15 yrs	340 - 1400
15 - <16 yrs	60 - 1220
16 - <20 yrs	60 - 720
20 – <25 yrs* * Please note values can be higher before growth plate closure.	15 - 115
25 – <70 yrs	15 - 80
≥ 70 yrs	15 - 115

Reference Interval Source:

1) Wyness S et al. Clinica Chimica Acta 2013; 169-172.

2) Vasikaran S, Chubb P, Schneider HG. Towards optimising the provision of laboratory services for bone turnover markers. Pathology 2014; 46(4):267-273.

Note: Reference Intervals above amended to include age related intervals for children from 28/09/2015

Assay performed on Roche cobas e801(ECLIA)

Note: Biotin supplementation may cause falsely low results due to interference with the P1NP assay. If the patient is known to be taking Biotin, interpret results with caution and contact the Chemical Pathologist (03) 90763118 if further discussion is required.