Pathology Handbook

Prostate Specific Antigen

PSA is more sensitive and specific for carcinoma of the prostate than prostatic Acid Phosphatase. Levels correlate well with tumour bulk and clinical stage, but significant elevations have also been seen in benign prostatic hypertrophy.

Reference Range:  

Age related Reference ranges introduced 3 Sept 2010

Males

0-30 days                  0.05 ug/L    

31 days - 7.99 years   <0.01 ug/L

8-17.99 years            <1.5 ug/L

18-29.99 years           0.2-2.0 ug/L

30-39.99 years           0.2-2.1ug/L

40-44.99 years           0.25-2.2 ug/L

45-49.99 years           0.25-2.5 ug/L

50-54.99 years           0.25-3.0 ug/L

55-59.99 years           0.3-3.5 ug/L

60-64.99 years           0.3-4.5 ug/L

65-69.99 years           0.3-5.5 ug/L

70-74.99 years           0.3-6.5 ug/L

75-79.99 years           0.3-7.5 ug/L

80-115 years              0.25-9.0 ug/L

Females                    <0.01 ug/L

Pregnancy                 <0.2 ug/L

Method used is Abbott Alinity (CMIA).

Ref: Sikaris KA, Caldwell G, “Age related reference intervals for the Architect PSA.” Clin Biochem Rev 2007:28:S33