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Pro-Brain Natriuretic Peptide

Alternative Names:

NTBNP
Pro-BNP

Laboratory:

Clinical Biochemistry

Test Code:

NTBNP

Specimen Types:

Serum
Plasma

Container Types:

SST
Lithium Heparin (with Gel)

Adults Volume or Mass:

4 mL

Minimum/Paediatric Volume or Mass:

4 mL

Transport Instructions between Sites and/or Laboratories:

Room Temperature

Assay Frequency:

Daily

Additional Notes:

From 3 August 2020- NTPro-BNP Assay performed on Abbott Alinity

Reference Intervals:

NTPro-BNP <125ng/L makes a diagnosis of congestive heart failure (CHF) very unlikely¹ , while a NTPro-BNP >150ng/L is associated with increased 10 year mortality².

Optimal sensitivity and specificity cut off for NTPro-BNP in CHF diagnosis in the ED was found with age-adjusted cut offs^3,4

Age < 50 >450ng/L

Age 50 -75 >900ng/L

Age >75 >1800ng/L

1) Ponikowski P et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.Eur J Heart Fail 2016;18(8):891-975.

2) Taylor CJ et al. The potential role of NT-proBNP in screening for and predicting prognosis in heart failure: a survival analysis. BMJ Open 2014;4:e004675

3) Januzzi JL et al. NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study. Eur Heart J. 2006;27(3):330-337.

4) Januzzi JL Jr et al. N-Terminal Pro-B-Type Natriuretic Peptide in the Emergency Department: The ICON-RELOADED Study. J Am Coll Cardiol. 2018;71(11):1191-1200.4)