Pathology Handbook

PLEASE NOTE: Recent changes have been made to this Test

Recent changes for Maternal Serum Screening (MSS)

Recent changes for Maternal Serum Screening (MSS)
Date	Field	Changed From	Changed To
28th March 2026	Assay name	Maternal Serum Screening	Maternal Serum Screening (MSS)
	Alternative names	Quadruple Test Fetal Screen	Quadruple Test Fetal Screen, MSS, CFTS, 2TMSS, Combined first trimester screening, Second trimester screening
	Preferred Specimen Type	Serum	Blood
	Collection & Request Instructions	Pre-natal screening for Down's Syndrome, other trisomies and neural tube defects is available in the form of 1st and 2nd trimester blood screening and/or ultrasound.	Combine first trimester screening (CFTS) (sample @9-13W6D) Second trimester maternal serum screening (2TMSS) (sample @14-20W6D) Pre-natal screening for Down's Syndrome, other trisomies and neural tube defects is available in the form of 1st and 2nd trimester blood screening and/or ultrasound.

Maternal Serum Screening (MSS)

Alternative Names:

Quadruple Test Fetal Screen
MSS
CFTS
2TMSS
Combined first trimester screening
Second trimester screening

Laboratory:

Clinical Biochemistry

Test Code:

MSS

Specimen Types:

Blood

Container Types:

SST

Collection & Request Instructions:

Combine first trimester screening (CFTS) (sample @9-13W6D)

Second trimester maternal serum screening (2TMSS) (sample @14-20W6D)

Pre-natal screening for Down's Syndrome, other trisomies and neural tube defects is available in the form of 1st and 2nd trimester blood screening and/or ultrasound.

Transport Instructions between Sites and/or Laboratories:

Room Temperature

External Laboratory:

Victorian Clinical Genetics Services, RC Hospital

Pathology Handbook

PLEASE NOTE: Recent changes have been made to this Test

Assay name

Alternative names

Preferred Specimen Type

Collection & Request Instructions

Maternal Serum Screening (MSS)