Pathology Handbook

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Posaconazole

Laboratory:

Clinical Biochemistry

Test Code:

POSA

Specimen Types:

Blood

Container Types:

EDTA 3 mL

Adults Volume or Mass:

2 mL

Minimum/Paediatric Volume or Mass:

2 mL

Collection & Request Instructions:

Collect pre-dose

Collect samples Pre Dose

Do not use tubes with gel separator.

Assay run 3 x weekly (Monday, Tuesday & Thursday) - samples must be in lab by 11AM on each day. Results available at end of the day.

Transport Instructions between Sites and/or Laboratories:

Room Temperature

Assay Frequency:

3 x weekly (thrice)

MBS Rebatable:

Yes

MBS Item No.:

66812

Additional Notes:

Method: LC-MS/MS

Therapeutic Ranges for Posaconazole

We suggest to monitor Posaconazole trough concentration at steady state (7 days after starting therapy). Levels ≥ 0.7 mg/L are required for prophylaxis and ≥ 1mg/L for invasive fungal infection.

Reference Interval Source:

Chau M, Kong D, van Hal J et al. Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014. Internal Medicine Journal 2014; 1364-1388.

Refer to Alfred PROMPT Posaconazole guideline for further details