Pathology Handbook

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Creutzfeldt-Jacob Disease Protein

Alternative Names:

CJD Protein
Protein 14-3-3

Laboratory:

Microbiology

Test Code:

CJD

Specimen Types:

Cerebrospinal Fluid

Container Types:

CSF Tube 3

Adults Volume or Mass:

1 mL

Collection & Request Instructions:

Department Head authorisation required (except Neurology patients).

Transport Instructions between Sites and/or Laboratories:

On Ice

Assay Frequency:

Weekly

External Laboratory:

CJD Registry

Additional Notes:

Notes:

(i) The 14-3-3 protein is a non-specific marker of central nervous system neuronal injury or death. Based on international experience in carefully selected patient, a positive result has approximately 90% sensitivity and specificity for sporadic CJD. “False” positives are frequently recognised in encephalitis (especially Herpes Simplex) and recent cerebral infarcts.

(ii) If the sample is haemorrhagic, a false positive result is likely. It is recommended that a repeat sample is submitted after 10 to 14 days.

Creutzfeld-Jakob Disease Testing includes 14-3-3 and RT-QulC.