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COPEPTIN

Alternative Names:

c-terminal proAVP

Laboratory:

Clinical Biochemistry

Test Code:

COPT

Specimen Types:

Blood

Container Types:

EDTA 3 mL

Adults Volume or Mass:

3 mL

Minimum/Paediatric Volume or Mass:

2 mL

Collection & Request Instructions:

Must be discussed with Chemical Pathologist

Collect at ambient temperature

Retrospective testing within 24 hrs

Transport Instructions between Sites and/or Laboratories:

On Ice

Assay Frequency:

Weekdays

External Laboratory:

Northern Pathology Victoria

Additional Notes:

Must be approved by Chemical Pathologist

This is a non-MBS test. Cost is $50

Results interpretation

A random copeptin of >/= 21.4 pmol/L is consistent with nephrogenic diabetes insipidus.

In the setting of hypernatremia, a copeptin <4.4 pmol/L is consistent with central diabetes insipidus.

In a hypertonic saline infusion test, once plasma sodium is >/= 147 mmol/L, a copeptin of >4.9 pmol/L suggests primary polydipsia and a copeptin of < and = 4.9 pmol/L is consistent with central diabetes insipidus.

Reference:

Christ-Crain et al, J Clin Endocrinol Metab 2022; 107: 1727-38.

Test performed on a BRAHMS Kryptor Compact PLUS at Northern Pathology Victoria from 15/12/2022.