Pathology Handbook

 New search
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # ALL

Mitotane

Laboratory:Clinical Biochemistry
Test Code:MITOTANE
Specimen Types:Plasma
Container Types:
EDTA 10 mL
Adults Volume or Mass:6 mL
Collection & Request Instructions:Collect pre-dose

It is recommended that a baseline (pre-treatment) blood sample, a trough level at 1, 2 and 4 weeks after starting treatment, and then regular checks of a trough level every 3 months, be performed.

Transport Instructions between Sites and/or Laboratories:Send to lab immediately
Assay Frequency:Fortnightly
External Laboratory:NSW Health Pathology, Calvary Mater Hospital
Additional Notes:

Ref. Range: 14 -20 mg/L

Serum Mitotane levels above 14 mg/L are associated with optimal therapeutic effect (Haak HR, et al. Br J Cancer 1994.69:947-951). Levels above 20 mg/L are associated with toxicity, mainly gastrointestinal and CNS adverse effects (Van Slooten H et al. Eur J Clin Oncol 1984. 20: 47 - 53, Baudin E et al. Cancer 2001. 92:1385-92).

Note: This test is not Medicare funded. Assay performed by a non NATA accredited research lab- Medical Oncology laboratory at Calvary Mater Newcastle Hospital.