Pathology Handbook

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Cyclosporin, or CSA

Laboratory:

Clinical Biochemistry

Test Code:

CYCLO or CYCLO POST

Specimen Types:

Blood

Container Types:

EDTA 3 mL

Collection & Request Instructions:

Collect pre-dose or 2hr post-dose.

Must be stated on request form!

Note: 2hr post-dose sample time is critical - collect sample 2hrs(+/- 10 mins) after previous dose.

Pre Dose only - Retrospective testing within 7 days.

Transport Instructions between Sites and/or Laboratories:

Room Temperature

Assay Frequency:

Daily

Additional Notes:

Therapeutic Ranges vary based on type of transplant and time post transplant.

CYCLOSPORIN THERAPEUTIC RANGES

These ranges are valid from the 8^th Jan 2010 using LCMSMS technology.

Cyclosporin levels in μg/L recommended trough (pre – dose)

Transplant Type	< 3 months	3 – 6 months	6 – 12 months	> 12 months
Heart	225 – 300	150 – 225	110 – 200	80 – 110
Lung	225 – 300	190 – 260	190 – 260	150 – 225
Kidney*	80 – 150	80 – 150	60 – 150	60 – 150
Bone Marrow	80 – 225	80 – 225

Cyclosporin levels recommended 2 Hr post – dose (C2)

Transplant Type	< 3 months	3 – 6 months	6 – 12 months	> 12 months
Heart	750 – 1000	450 – 750	450 – 750	300 – 600
Lung	600 – 1100	530 – 900	450 – 700	450 – 600
Kidney*	750 – 1000	600 –750	400 – 600	400 – 600

NB: For Kidney Transplantation C2 is preferred.

Note: No information is available as to the desired range when the drug is used as an immuno-suppressive agent for auto-immune or similar conditions.

(Reference Range Source: Developed in consultation with The Alfred Transplantation Units and A/Prof. H-G Schneider, Alfred Pathology Service, 2010).