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PLEASE NOTE: Recent changes have been made to this Test


 Recent changes for Clozapine

Recent changes for Clozapine
DateFieldChanged FromChanged To
26th June 2020
Optional Specimen Type

Serum

Optional Container Type

EDTA 3 mL

EDTA 3 mL
Plain tube - serum (no Gel)

Clozapine

Laboratory:Clinical Biochemistry
Test Code:CLOZAH for Alfred, CLOZO for Outside tests
Specimen Types:Plasma
Serum
Container Types:
Lithium Heparin (without Gel)
EDTA 3 mL
Plain tube - serum (no Gel)
Adults Volume or Mass:2 mL
Collection & Request Instructions:Collect pre-dose
Transport Instructions between Sites and/or Laboratories:Room Temperature
Assay Frequency:Weekly
Additional Notes:

Evidence suggests that clozapine plasma levels of at least 250-350 mcg/L are required for optimal clinical response.

Our recommended therapeutic range (Clozapine levels 350-600 mcg/L) follows the consensus guidelines published in psychopharmacology in 2018 (1). Only about 1/3 of patients show drug levels within that range. Some patients will require higher clozapine concentrations of up to 800 mcg/L for disease control without increased levels of side effects.

Hiemke C, et al. Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017. Pharmacopsychiatry. 2018 Jan;51(1-02):e1. doi: 10.1055/s-0037-1600991. Epub 2018 Feb 1.

 

Clozapine Assay performed  by Alfred Pathology Service from 14 Jan 2020