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P1NP

Alternative Names:Procollagen type 1 amino-terminal peptide
Laboratory:Clinical Biochemistry
Test Code:P1NP
Specimen Types:Plasma
Serum
Container Types:
EDTA 6 mL
SST
Lithium Heparin (with Gel)
Collection & Request Instructions:

Marker of bone formation. Useful for monitoring effect of anti-resorptive therapy and patient compliance.

 

Note: For retrospective test requests;

Serum , K3-EDTA plasma and  Li-heparin plasma are stable for 24 hrs at 15 -25 C, 5 days at 2 - 8C,   6 months at -20C. Samples may be frozen and thawed up to 5 times without adverse effects.

K3-EDTA plasma is our preferred specimen.

Transport Instructions between Sites and/or Laboratories:Room Temperature
Assay Frequency:Weekdays
Additional Notes:

REFERENCE INTERVALS

P1NP – Serum procollagen type 1 amino-terminal propeptide

 

Female:

 

Age

Reference intervals: ug/L

6 – <12 months

840-1800

1 - <2yrs

600-1500

2 - <3yrs

400-1150

3 – <6 yrs

300-900

6 – <11 yrs

410 - 1020

11 - < 12 yrs

110 - 1450

12 –< 15 yrs

110 - 1350

15 - < 16yrs

40 - 510

16 – <20 yrs

50 - 280

20 – <25 yrs

15 - 90

25 – <50 yrs*

* This reference interval applies to pre-menopausal women, values can be higher in < 35 y.o.

15 - 70

50 – <70 yrs*

* This reference interval applies to post- menopausal women.

15 - 90

≥ 70 yrs

15 - 115

 

Male:

 

Age

Reference intervals: ug/L

6 – <12 months

840-1800

1 - <2 yrs

600-1500

2 - <3 yrs

400-1150

3 – <6 yrs

300-900

6 - <12 yrs

410 - 1080

12 – <15 yrs

340 - 1400

15 - <16 yrs

60 - 1220

16 - <20 yrs

60 - 720

20 – <25 yrs*

* Please note values can be higher before growth plate closure.

15 - 115

25 – <70 yrs

15 - 80

≥ 70 yrs

15 - 115

Reference Interval Source:

1) Wyness S et al. Clinica Chimica Acta 2013; 169-172.

2) Vasikaran S, Chubb P, Schneider HG. Towards optimising the provision of laboratory services for bone turnover markers. Pathology 2014; 46(4):267-273.

Note: Reference Intervals above amended to include age related intervals for children from 28/09/2015

Assay performed on Roche Elecsys(ECLIA)

Note: Biotin supplementation may cause falsely low results due to interference with the P1NP assay. If the patient is known to be taking Biotin, interpret results with caution and contact the Chemical Pathologist (03) 90763118 if further discussion is required.