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Renin Ambulant

Laboratory:Clinical Biochemistry
Test Code:REN-A
Specimen Types:Plasma
Container Types:
EDTA 6 mL
Collection & Request Instructions:Retrospective testing not possible.

Endocrine consultation is required in planning renal vein sampling.

Transport Instructions between Sites and/or Laboratories:Room Temperature
Send to lab immediately

 

If specimens are collected from a location external to Alfred Pathology, they should be spun and the plasma frozen at -80 C. Please note that freezing at -20 C is NOT sufficient and may cause cryo-activation of pro-renin leading to falsely high results.

Once frozen at -80 C, samples can be transferred to, or transported at, -20 C.

 

Assay Frequency:Twice weekly
Additional Notes:

 

Reference Interval:  4.4 - 46.1 mIU/L

Source: Diasorin Liaison kit insert 200/007-906,06-2016-04

ARR- aldosterone renin ratio

Aldosterone-Renin Ratio (ARR) is a screening test not a diagnostic test for primary hyperaldosteronism. As of 08/06/2017 Aldosterone and Renin are being performed on the Diasorin Liaison XL platform. Please note changed reference intervals.

An aldosterone-renin ratio cut-off of > 70 should prompt further investigation for primary hyperaldosteronism in the appropriate clinical setting. Lower cut-offs improve sensitivity with a loss in specificity whereas higher cut-offs are more specific for primary hyperaldosteronism (with a concomitant loss in sensitivity).

Reference: The Endocrine Society clinical practice guideline on primary hyperaldosteronism,  Funder JW, Carey RM, Mantero F, et al. J Clin Endocrinol Metab 101:1889-1916, 2016

Note: Renin is measured as direct renin mass (mIU/L) rather than plasma renin activity (µg/L/hr) previously. There is no conversion factor for the two assays. Compared to plasma renin activity, renin mass is reduced in high estrogen states (oral contraceptive pill) and increased in patients taking renin inhibitors.