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PLEASE NOTE: Recent changes have been made to this Test


 Recent changes for Pro-Brain Natriuretic Peptide

Recent changes for Pro-Brain Natriuretic Peptide
DateFieldChanged FromChanged To
11th August 2020
Volume (Adults)

4.0 mL

Minimum/Paediatric Volume

4.0 mL

Collection & Request Instructions

Retrospective Addons:

Specimen stable for 3 days at 20-25C, 6 days at 2-8C, 24 mths at -20C.

Minumum specimen volume:  500 uL

Frequency

Daily

Pro-Brain Natriuretic Peptide

Alternative Names:NTBNP
Pro-BNP
Laboratory:Clinical Biochemistry
Test Code:NTBNP
Specimen Types:Serum
Plasma
Container Types:
SST
Lithium Heparin (with Gel)
Adults Volume or Mass:4 mL
Minimum/Paediatric Volume or Mass:4 mL
Transport Instructions between Sites and/or Laboratories:Room Temperature
Assay Frequency:Daily
Additional Notes:

 

 

From 3 August 2020-  NTPro-BNP Assay performed on Abbott Alinity

Reference Intervals:

NTPro-BNP <125ng/L makes a diagnosis of congestive heart failure (CHF) very unlikely1 , while a NTPro-BNP >150ng/L is associated with increased 10 year mortality2.

Optimal sensitivity and specificity cut off for NTPro-BNP in CHF diagnosis in the ED was found with age-adjusted cut offs3,4

Age < 50            >450ng/L

Age 50 -75         >900ng/L

Age >75             >1800ng/L

1) Ponikowski P et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.Eur J Heart Fail 2016;18(8):891-975.

2) Taylor CJ et al. The potential role of NT-proBNP in screening for and predicting prognosis in heart failure: a survival analysis. BMJ Open 2014;4:e004675

3) Januzzi JL et al. NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study. Eur Heart J. 2006;27(3):330-337.

4) Januzzi JL Jr et al. N-Terminal Pro-B-Type Natriuretic Peptide in the Emergency Department: The ICON-RELOADED Study. J Am Coll Cardiol. 2018;71(11):1191-1200.4)