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Holotranscobalamin

Laboratory:Clinical Biochemistry
Test Code:HOLOTC
Specimen Types:Serum
Container Types:
SST
Collection & Request Instructions:

The transcobalamin-vitamin B12 complex (Holotranscobalamin) contains the biologically active cobalamin. A decrease of Holotranscobalamin is one of the earliest markers of cobalamin deficiency.

Retrospective testing - Note Sample MUST be Serum.

• Specimens may be stored on or off the clot for up to 16 hours at room temperature or up to 3 days at 2-8°C.If testing will be delayed more than 3 days, remove serum from the clot and store at -20°C or colder. Avoid more than 3 freeze/thaw cycles.

Reference for Retrospective Testing: Abbott Architect Active B12 kit insert 2011.

 

 

Transport Instructions between Sites and/or Laboratories:Room Temperature
Additional Notes:

Reference Range:  23—100 pmol/L

Holotranscobalamin (HOLOTC) measures the biologically available fraction of Vitamin B12.

<23 pmol/L           Vitamin B12 deficient  

23-35 pmol/L        Borderline low B12. Suggest review of clinical information together with confirmatory laboratory tests. For Further information contact Haematology registrars on ext 63075.

>35 pmol/L           Vitamin B12 normal

Assay transferred from Abbott Axsym (MEIA) to Abbott Architect (CMIA) 20-6-2012