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C-Telopeptide

Alternative Names:CTX
Laboratory:Clinical Biochemistry
Test Code:CTX
Specimen Types:Plasma
Container Types:
EDTA 6 mL
SST
Collection & Request Instructions:Collect in am
Fasting Sample

Marker of bone resorption. Useful for monitoring the effect of anti-resorptive therapy and patient compliance.

Plasma EDTA is the preferred sample as it is stable longer than serum.

Stability of K2- and K3-EDTA plasma: 24 hrs at 20-25C, 8 days at 2-8C

3 months at -20C. For longer periods store at -70C. Freeze only ONCE.

Serum is only stable 6 hrs at 20-25 C, 8 hrs at 4 - 8C,         3 months at -20C. For longer periods store at -70C. Freeze only ONCE

Haemolyzed samples (Hb> 0.5 g/dL) elicit a decrease in the C-Telopeptide (Beta- crosslaps) concentration.

 

Transport Instructions between Sites and/or Laboratories:Send to lab immediately
Use Esky from SDMH or CGMC to Alfred

For external sites transport to Alfred Pathology  Frozen.

Assay Frequency:Weekdays
Additional Notes:

Reference Intervals:

CTX – C-Telopeptide – Serum carboxy-terminal cross-linking telopeptide of type 1 collagen

 

Female:

 

Age

Reference intervals: ng/L

6 months – < 6 yrs

450 – 1800

6  – <11 yrs

820 - 2010

11 – <15 yrs

490 - 2760

15 - <16yrs

120-1730

16 – <20 yrs

120 - 1590

20 – <50yrs*

*This reference interval applies to pre-menopausal women, values can be higher in < 40 y.o.

150  – 800

50 – <70yrs *

*This reference interval applies to post- menopausal women.

50  –  800

≥ 70 yrs

100  – 1000

 

Male:

 

Age

Reference intervals: ng/L

6 months – < 6 yrs

450 – 1800

6  – <10 yrs

1050 - 2380

10 – <16 yrs

1000 - 2900

16 - <20 yrs

500 - 2430

20 – <25  yrs*

*Please note values can be higher before growth plate closure.

400 – 900

25 – <70 yrs

100 –  600

≥ 70 yrs

100 – 750

 

 

Reference Interval Sources:

1) Wyness S et al. Clinica Chimica Acta 2013; 169-172.

2) Vasikaran S, Chubb P, Schneider HG. Towards optimising the provision of laboratory services for bone turnover markers. Pathology 2014; 46(4):267-273.

Note: Higher levels may be seen in women < 40 yrs.

Note: Reference Intervals above amended to include age related intervals for children from 28/09/2015.

Assay performed on Roche Elecsys (ECLIA)

Note: Biotin supplementation may cause falsely low results due to interference with the C-Telopeptide assay. If the patient is known to be taking Biotin, interpret results with caution and contact the Chemical Pathologist (03) 90763118 if further discussion is required.