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PLEASE NOTE: Recent changes have been made to this Test


 Recent changes for Posaconazole

Recent changes for Posaconazole
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Posaconazole

Laboratory:Clinical Biochemistry
Test Code:POSA
Specimen Types:Plasma
Container Types:
EDTA 10 mL
Adults Volume or Mass:5 mL
Collection & Request Instructions:Collect pre-dose

Collect samples Pre Dose

Do not use tubes with gel separator.

Assay run 3 x weekly  (Monday, Tuesday & Thursday) - samples must be in lab by 11AM on each day.                               Results available at end of the day.

Transport Instructions between Sites and/or Laboratories:Room Temperature
Assay Frequency:3 x weekly (thrice)
Additional Notes:

Therapeutic Ranges for Posaconazole

 We suggest to monitor Posaconazole trough concentration at steady state (7 days after starting therapy). Levels ≥ 0.7 mg/L are required for prophylaxis and ≥ 1mg/L for invasive fungal infection. 

Reference Interval Source:

Chau M, Kong D, van Hal J et al. Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014. Internal Medicine Journal 2014; 1364-1388.

Refer to Alfred PROMPT Posaconazole guideline for further details