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Mycophenolic Acid

Laboratory:Clinical Biochemistry
Test Code:MYCOP
Specimen Types:Plasma
Container Types:
EDTA 10 mL
Adults Volume or Mass:5 mL
Collection & Request Instructions:Collect pre-dose
Transport Instructions between Sites and/or Laboratories:On Ice
Assay Frequency:Weekly
External Laboratory:Austin Pathology
Additional Notes:

Pre-Dose - Pre-Dose sampling is useful for checking patient compliance or suspected toxicity. A universal reference range is not applicable.  Correlation between Pre-dose plasma levels of total MPA and clinical outcome depend on the specific clinical setting/patient population and have not been firmly established in some settings.

 

Mycophenolic acid (MPA) total, estimation of AUC 0-12 hr - plasma.

Estimation of AUC 0-12 hr uses a limited sampling approach.  It requires 4 samples (Pre-dose, +1hr, +2 hr, +4hr post dose).

FORMS to be COMPLETED and sent to lab with the samples.

To ensure capture of all data a completed copy of the specific form -downloadable from www.austinpathology.org.au/test-directory      MUST be sent to the lab with the samples for the MPAAUC tests.

A reference range is currently being established. In renal and cardiac transplant recipients an AUC 0-12 hr of 30 to 60 mg.hr/L in the initial phase after transplantation has been shown to associate with less rejection (see Elbarbry FA and Shoker AS, 2007, Clin. Biochem 40:752 for review).

For further information please contact Andrew Ellis, Clinical    Pharmacology and Therapeutics Unit, Austin Pathology on 94963220.

Chemical Pathologist/Registrar approval required - to ensure all forms completed and samples (AUC) collated - prior to sending to Austin Pathology