Pre-Dose - Pre-Dose sampling is useful for checking patient compliance or suspected toxicity. A universal reference range is not applicable. Correlation between Pre-dose plasma levels of total MPA and clinical outcome depend on the specific clinical setting/patient population and have not been firmly established in some settings.
Mycophenolic acid (MPA) total, estimation of AUC 0-12 hr - plasma.
Estimation of AUC 0-12 hr uses a limited sampling approach. It requires 4 samples (Pre-dose, +1hr, +2 hr, +4hr post dose).
FORMS to be COMPLETED and sent to lab with the samples.
To ensure capture of all data a completed copy of the specific form -downloadable from www.austinpathology.org.au/test-directory MUST be sent to the lab with the samples for the MPAAUC tests.
A reference range is currently being established. In renal and cardiac transplant recipients an AUC 0-12 hr of 30 to 60 mg.hr/L in the initial phase after transplantation has been shown to associate with less rejection (see Elbarbry FA and Shoker AS, 2007, Clin. Biochem 40:752 for review).
For further information please contact Andrew Ellis, Clinical Pharmacology and Therapeutics Unit, Austin Pathology on 94963220.
Chemical Pathologist/Registrar approval required - to ensure all forms completed and samples (AUC) collated - prior to sending to Austin Pathology