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Creutzfeldt-Jacob Disease Protein

Alternative Names:CJD Protein
Protein 14-3-3
Laboratory:Microbiology
Test Code:CJD
Specimen Types:Cerebrospinal Fluid
Container Types:
CSF Tube 3
Adults Volume or Mass:1 mL
Collection & Request Instructions:

Department Head authorisation required (except Neurology patients).

Transport Instructions between Sites and/or Laboratories:On Ice
Assay Frequency:Weekly
External Laboratory:CJD Registry
Additional Notes:

Notes:

(i)        The 14-3-3 protein is a non-specific marker of central nervous system neuronal injury or death. Based on international experience in carefully selected patient, a positive result has approximately 90% sensitivity and specificity for sporadic CJD. “False” positives are frequently recognised in encephalitis (especially Herpes Simplex) and recent cerebral infarcts.

(ii)   If the sample is haemorrhagic, a false positive result is likely. It is recommended that a repeat sample is submitted after 10 to 14 days.

Creutzfeld-Jakob Disease Testing includes 14-3-3 and RT-QulC.