(i) The 14-3-3 protein is a non-specific marker of central nervous system neuronal injury or death. Based on international experience in carefully selected patient, a positive result has approximately 90% sensitivity and specificity for sporadic CJD. “False” positives are frequently recognised in encephalitis (especially Herpes Simplex) and recent cerebral infarcts.
(ii) If the sample is haemorrhagic, a false positive result is likely. It is recommended that a repeat sample is submitted after 10 to 14 days.