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PLEASE NOTE: Recent changes have been made to this Test


 Recent changes for COPEPTIN

Recent changes for COPEPTIN
DateFieldChanged FromChanged To
22nd December 2023
Frequency

Monthly

Weekdays

COPEPTIN

Alternative Names:c-terminal proAVP
Laboratory:Clinical Biochemistry
Test Code:COPT
Specimen Types:Blood
Container Types:
EDTA 3 mL
Adults Volume or Mass:3 mL
Minimum/Paediatric Volume or Mass:2 mL
Collection & Request Instructions:Must be discussed with Chemical Pathologist

Collect at ambient temperature

Retrospective testing within 24 hrs

Transport Instructions between Sites and/or Laboratories:On Ice
Assay Frequency:Weekdays
External Laboratory:Northern Pathology Victoria
Additional Notes:

Must be approved by Chemical Pathologist

This is a non-MBS test.  Cost is $50

Results interpretation

A random copeptin of >/= 21.4 pmol/L is consistent with nephrogenic diabetes insipidus.

In the setting of hypernatremia, a copeptin <4.4 pmol/L is consistent with central diabetes insipidus.

In a hypertonic saline infusion test, once plasma sodium is >/= 147 mmol/L, a copeptin of >4.9 pmol/L suggests primary polydipsia and a copeptin of < and = 4.9 pmol/L is consistent with central diabetes insipidus.

Reference:

Christ-Crain et al, J Clin Endocrinol Metab 2022; 107: 1727-38.

Test performed on a BRAHMS Kryptor Compact PLUS at Northern Pathology Victoria from 15/12/2022.