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PLEASE NOTE: Recent changes have been made to this Test


 Recent changes for Levetiracetam

Recent changes for Levetiracetam
DateFieldChanged FromChanged To
12th May 2022
Volume (Adults)

0.5 mL

3 mL

Minimum/Paediatric Volume

0.5 mL

3 mL

Collection & Request Instructions

Collect pre dose.

Frequency

Twice weekly

Weekly

Levetiracetam

Alternative Names:Keppra
Laboratory:Clinical Biochemistry
Test Code:LEVET
Specimen Types:Plasma
Serum
Container Types:
Lithium Heparin (without Gel)
Plain tube - serum (no Gel)
Adults Volume or Mass:3 mL
Minimum/Paediatric Volume or Mass:3 mL
Collection & Request Instructions:

Collect pre dose.

Transport Instructions between Sites and/or Laboratories:Use Esky from SDMH or CGMC to Alfred
Assay Frequency:Weekly
Additional Notes:

Levetiracetam is an antiepileptic drug that is used as monotherapy for partial seizures as well as an adjunct in partial, myoclonic and generalised tonic-clonic seizures. It shows a rapid absorption after oral administration and has linear pharmacokinetics. It is renally excreted (the majority unchanged and about ¼ as an inactive metabolite). The serum half life in adults is 6 to 8 hours. For therapeutic drug monitoring a trough level is recommended.

Previously a therapeutic range from 12 to 46 mg/L has been recommended (1). Newer data from New South Wales recommend a therapeutic range 20 to 40 mg/L based on freedom from epileptic fits both in patients on monotherapy as well as in patients where multiple antiepileptic medications are used (2).

Suggested therapeutic range: 20 to 40 mg/L

  1. Krasowski MD Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications Pharmaceuticals (Basel). 2010 Jun 11;3(6):1909-1935. doi: 10.3390/ph3061909.
  2. Stepanova D, Beran RG. Measurement of levetiracetam drug levels to assist with seizure control and monitoring of drug interactions with other anti-epileptic medications (AEMs) Seizure. 2014 May;23(5):371-6.